PhD student in CHO Cell Line Engineering and Design
Danmarks Tekniske Universitet
Hørsholm, 1 stilling
We are seeking a highly ambitious and talented PhD student to work on interdisciplinary projects within engineering and design of Chinese hamster ovary (CHO) cells for biotechnological applications. The PhD student will work close together with other researchers in the CHO Cell Line Engineering and Design section at the Novo Nordisk Foundation Center for Biosustainability (DTU Biosustain).
Job description
The PhD student will join a larger research project focusing on optimizing host cells for the production of therapeutic proteins. The PhD student will identify target genes, design genetic engineering strategies, screen and characterize cell lines. The work will include application of CRISPR/Cas9 genome editing technologies and systems biology techniques in addition to development of high through-put assays. The candidate will work closely with other research groups and core facilities that aim at constructing superior cell factories and develop technologies that shorten the design cycle in cell line engineering.
Qualifications
Mandatory requirements:
•Master degree in biology, biochemistry, biotechnology or bioengineering
•Laboratory experience with molecular and cell biology of eukaryotic cells
•Strong work ethic and motivation to succeed within a competitive research field
•Good communication skills
Preference given to a candidate with experience in:
•Mammalian cell handling
•Molecular biology techniques
•Microscopy and cell sorting
•Biotechnology and cell biology
Approval and Enrolment
The scholarships for the PhD degree are subject to academic approval, and the candidates will be enrolled in one of the general degree programs of DTU. For information about the general requirements for enrolment and the general planning of the scholarship studies, please see the DTU PhD Guide.
Assessment
The assessment of the applicants will be made by Co-Principal Investigator Helene Faustrup Kildegaard.
We offer
We offer an interesting and challenging job in an international environment focusing on research and innovation, which contribute to enhancing the economy and improving social welfare. We strive for academic excellence, collegial respect and freedom tempered by responsibility. The Technical University of Denmark (DTU) is a leading technical university in northern Europe and benchmarks with the best universities in the world.
Salary and appointment terms
The salary and appointment terms are consistent with the current rules for PhD degree students. The period of employment is 3 years. Place of work will be DTU Biosustain, Kogle Allé 6, Hørsholm.
Further information
Further information may be obtained from Co-Principal Investigator Helene Faustrup Kildegaard, +45 20 12 46 29, hef@biosustain.dtu.dk.
Please do not send applications to this e-mail address, instead apply online as described below.
You can read more about CFB on <a href='javascript:openLinkWindow("http://www.biosustain.dtu.dk")' "="" data-cke-saved-href='javascript:openLinkWindow("http://www.biosustain.dtu.dk")'>http://www.biosustain.dtu.dk.
Application
Please submit your online application no later than 24 October 2015.
Applications must be submitted as one pdf file containing all materials to be given consideration. To apply, please open the link "Apply online," fill in the online application form, and attach all your materials in English in one pdf file. The file must include:
•A letter motivating the application (cover letter)
•Curriculum vitae
•Grade transcripts and BSc/MSc diploma
•Excel sheet with translation of grades to the Danish grading system (see guidelines and excel spreadsheet here)
Candidates may apply prior to obtaining their master's degree, but cannot begin before having received it.
All interested candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply.
DTU Biosustain is an international research center of excellence developing next generation cell factories and bioprocesses for sustainable production of high-value chemical compounds as well as protein-based products. The center uses advanced metabolic engineering techniques and computational biology ensuring efficient and cost-effective design and construction processes.
The center’s activities are a balanced mix of basic and translational research, complemented by an emphasis on business development to facilitate commercialization of new cell factories and associated technologies. DTU Biosustain offers state-of-the-art research facilities and assembles world leaders in the field thus, offering a unique platform providing excellent talent development and career opportunities.
DTU is a technical university providing internationally leading research, education, innovation and public service. Our staff of 5,800 advance science and technology to create innovative solutions that meet the demands of society; and our 10,300 students are being educated to address the technological challenges of the future. DTU is an independent academic university collaborating globally with business, industry, government, and public agencies.
